Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape
The provision of costimulatory signals to T cells are known to be vital in the direction and induction of a T cell driven response. Here the authors show an optimal T cell response requires a costimulatory induced modification of the transcript landscape and achieves this via modulation of the RNA b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31228-0 |
| _version_ | 1811334255469395968 |
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| author | Timofey A. Karginov Antoine Ménoret Anthony T. Vella |
| author_facet | Timofey A. Karginov Antoine Ménoret Anthony T. Vella |
| author_sort | Timofey A. Karginov |
| collection | DOAJ |
| description | The provision of costimulatory signals to T cells are known to be vital in the direction and induction of a T cell driven response. Here the authors show an optimal T cell response requires a costimulatory induced modification of the transcript landscape and achieves this via modulation of the RNA binding proteins. |
| first_indexed | 2024-04-13T17:05:06Z |
| format | Article |
| id | doaj.art-5f9acd8e70524ef1a3d9a323352fee0e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T17:05:06Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5f9acd8e70524ef1a3d9a323352fee0e2022-12-22T02:38:29ZengNature PortfolioNature Communications2041-17232022-06-0113111310.1038/s41467-022-31228-0Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscapeTimofey A. Karginov0Antoine Ménoret1Anthony T. Vella2Department of Immunology, School of Medicine, University of Connecticut, UConn HealthDepartment of Immunology, School of Medicine, University of Connecticut, UConn HealthDepartment of Immunology, School of Medicine, University of Connecticut, UConn HealthThe provision of costimulatory signals to T cells are known to be vital in the direction and induction of a T cell driven response. Here the authors show an optimal T cell response requires a costimulatory induced modification of the transcript landscape and achieves this via modulation of the RNA binding proteins.https://doi.org/10.1038/s41467-022-31228-0 |
| spellingShingle | Timofey A. Karginov Antoine Ménoret Anthony T. Vella Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape Nature Communications |
| title | Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape |
| title_full | Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape |
| title_fullStr | Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape |
| title_full_unstemmed | Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape |
| title_short | Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape |
| title_sort | optimal cd8 t cell effector function requires costimulation induced rna binding proteins that reprogram the transcript isoform landscape |
| url | https://doi.org/10.1038/s41467-022-31228-0 |
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