Characterization of ibrutinib's effects on the morphology, proliferation, phenotype, viability, and anti-inflammatory potential of adipose-derived mesenchymal stromal cells

Characterization of ibrutinib's effects on the morphology, proliferation, phenotype, viability, and anti-inflammatory potential of adipose-derived mesenchymal stromal cells

Abstract Ibrutinib (IB) is a tyrosine kinase inhibitor (TKI) that has immunomodulatory action and can be used as second-line therapy for steroid-refractory or steroid-resistant chronic Graft versus Host Disease (cGVHD). Mesenchymal stromal cells (MSCs) are distributed throughout the body and their i...

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Bibliographic Details
Main Authors: Amandda Évelin Silva-Carvalho, Elizabete Cristina Iseke Bispo, Ingrid Gracielle Martins da Silva, José Raimundo Correa, Juliana Lott Carvalho, Guilherme Martins Gelfuso, Felipe Saldanha-Araujo
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
Mesenchymal stromal cells; Ibrutinib
Tregs
VCAM-1
T-cells
Online Access:https://doi.org/10.1038/s41598-024-71054-6

Internet

https://doi.org/10.1038/s41598-024-71054-6

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