Synthesis of 4,5-Dihydro-1<i>H</i>-[1,2]dithiolo[3,4-<i>c</i>]quinoline-1-thione Derivatives and Their Application as Protein Kinase Inhibitors

Synthesis of 4,5-Dihydro-1<i>H</i>-[1,2]dithiolo[3,4-<i>c</i>]quinoline-1-thione Derivatives and Their Application as Protein Kinase Inhibitors

This study represents the design and synthesis of a new set of hybrid and chimeric derivatives of 4,5-dihydro-4,4-dimethyl-1<i>H</i>-[1,2]dithiolo[3,4-<i>c</i>]quinoline-1-thiones, the structure of which the tricyclic fragment linearly bound or/and condensed with another hete...

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Bibliographic Details
Main Authors: Svetlana M. Medvedeva, Khidmet S. Shikhaliev
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
1,2-dithiol-3-thione
2,2-disubstituted-1,2-dihydroquinolines
dithioloquinolinethiones
non-selective anti-kinase activity
bioactivity profiles prediction in silico
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Online Access:https://www.mdpi.com/1420-3049/27/13/4033

Internet

https://www.mdpi.com/1420-3049/27/13/4033

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