Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies
Abstract As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows minimal chances for developing resistance and has been recognized as a promising broad-spectrum antitumor d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02223-4 |
| _version_ | 1797414104912101376 |
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| author | Xiang Yu Siyu Jia Shi Yu Yaohui Chen Chengwei Zhang Haidan Chen Yanfeng Dai |
| author_facet | Xiang Yu Siyu Jia Shi Yu Yaohui Chen Chengwei Zhang Haidan Chen Yanfeng Dai |
| author_sort | Xiang Yu |
| collection | DOAJ |
| description | Abstract As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows minimal chances for developing resistance and has been recognized as a promising broad-spectrum antitumor drug because of this unique dual mechanism of action. However, MLT still displays obvious toxic side effects during treatment, such as nonspecific cytolytic activity, hemolytic toxicity, coagulation disorders, and allergic reactions, seriously hampering its broad clinical applications. With thorough research on antitumor mechanisms and the rapid development of nanotechnology, significant effort has been devoted to shielding against toxicity and achieving tumor-directed drug delivery to improve the therapeutic efficacy of MLT. Herein, we mainly summarize the potential antitumor mechanisms of MLT and recent progress in the targeted delivery strategies for tumor therapy, such as passive targeting, active targeting and stimulus-responsive targeting. Additionally, we also highlight the prospects and challenges of realizing the full potential of MLT in the field of tumor therapy. By exploring the antitumor molecular mechanisms and delivery strategies of MLT, this comprehensive review may inspire new ideas for tumor multimechanism synergistic therapy. |
| first_indexed | 2024-03-09T05:28:18Z |
| format | Article |
| id | doaj.art-5fa19b5e281b4cd58808c1584714e112 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-09T05:28:18Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-5fa19b5e281b4cd58808c1584714e1122023-12-03T12:34:58ZengBMCJournal of Nanobiotechnology1477-31552023-11-0121112210.1186/s12951-023-02223-4Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategiesXiang Yu0Siyu Jia1Shi Yu2Yaohui Chen3Chengwei Zhang4Haidan Chen5Yanfeng Dai6State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityThe First College of Clinical Medical Science, China Three Gorges UniversityState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan UniversityAbstract As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows minimal chances for developing resistance and has been recognized as a promising broad-spectrum antitumor drug because of this unique dual mechanism of action. However, MLT still displays obvious toxic side effects during treatment, such as nonspecific cytolytic activity, hemolytic toxicity, coagulation disorders, and allergic reactions, seriously hampering its broad clinical applications. With thorough research on antitumor mechanisms and the rapid development of nanotechnology, significant effort has been devoted to shielding against toxicity and achieving tumor-directed drug delivery to improve the therapeutic efficacy of MLT. Herein, we mainly summarize the potential antitumor mechanisms of MLT and recent progress in the targeted delivery strategies for tumor therapy, such as passive targeting, active targeting and stimulus-responsive targeting. Additionally, we also highlight the prospects and challenges of realizing the full potential of MLT in the field of tumor therapy. By exploring the antitumor molecular mechanisms and delivery strategies of MLT, this comprehensive review may inspire new ideas for tumor multimechanism synergistic therapy.https://doi.org/10.1186/s12951-023-02223-4MelittinImmunomodulatorySide effectsTumorMultimechanism |
| spellingShingle | Xiang Yu Siyu Jia Shi Yu Yaohui Chen Chengwei Zhang Haidan Chen Yanfeng Dai Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies Journal of Nanobiotechnology Melittin Immunomodulatory Side effects Tumor Multimechanism |
| title | Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies |
| title_full | Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies |
| title_fullStr | Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies |
| title_full_unstemmed | Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies |
| title_short | Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies |
| title_sort | recent advances in melittin based nanoparticles for antitumor treatment from mechanisms to targeted delivery strategies |
| topic | Melittin Immunomodulatory Side effects Tumor Multimechanism |
| url | https://doi.org/10.1186/s12951-023-02223-4 |
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