Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity.

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here...

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Bibliographic Details
Main Authors: C S James Ho, Anna Rydstrom, Malathy Sony Subramanian Manimekalai, Catharina Svanborg, Gerhard Grüber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3531425?pdf=render