UHRF1/DNMT1–MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

UHRF1/DNMT1–MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity (ITH). Protease serine 3 (PRSS3), possessing four splice variants (PRSS3-SVs; PRSS3-V1–V4),...

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Bibliographic Details
Main Authors: Shuye Lin, Hanli Xu, Lin Qin, Mengdi Pang, Ziyu Wang, Meng Gu, Lishu Zhang, Cong Zhao, Xuefeng Hao, Zhiyun Zhang, Weimin Ding, Jianke Ren, Jiaqiang Huang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lung cancer
Intratumor heterogeneity
Splice variants
Intragenic CpG methylation
Protease serine 3
Myeloid zinc finger 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000576

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http://www.sciencedirect.com/science/article/pii/S2211383523000576

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