Striatal miR-183-5p inhibits methamphetamine-induced locomotion by regulating glucocorticoid receptor signaling

Striatal miR-183-5p inhibits methamphetamine-induced locomotion by regulating glucocorticoid receptor signaling

MicroRNA (miRNA)-mediated striatal gene regulation may play an important role in methamphetamine (METH) addiction. This study aimed to identify changes in novel miRNAs and their target genes during METH self-administration and investigate their roles in METH-induced locomotion. RNA sequencing analys...

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Bibliographic Details
Main Authors: Sang-Hoon Song, Won-Jun Jang, Eun Young Jang, Oc-Hee Kim, Haesoo Kim, Taekwon Son, Dong-Young Choi, Sooyeun Lee, Chul-Ho Jeong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
methamphetamine
RNA sequencing
microRNA
self-administration
locomotor activity
glucocorticoid receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.997701/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.997701/full

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