Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia

Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia

Type 1 spinocerebellar ataxia (SCA1) is a progressive neurodegenerative disorder with no effective treatment to date. Using mice modeling SCA1, it has been demonstrated that a drug that amplifies mGlu1 receptor activation (mGlu1 receptor PAM, Ro0711401) improves motor coordination without the develo...

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Bibliographic Details
Main Authors: Francesca Liberatore, Nico Antenucci, Daniel Tortolani, Giada Mascio, Federico Fanti, Manuel Sergi, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, Mauro Maccarrone, Serena Notartomaso
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
SCA1
mGlu1 receptor
endocannabinoids
hippocampus
learning and memory
Online Access:https://www.mdpi.com/2073-4409/11/23/3916

Internet

https://www.mdpi.com/2073-4409/11/23/3916

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