In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence

Abstract Recurrent cancer cells that evade therapy is a leading cause of death in breast cancer patients. This risk is high for women showing an overexpression of human epidermal growth factor receptor 2 (Her2). Cells that persist can rely on different substrates for energy production relative to th...

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Bibliographic Details
Main Authors: Megan C. Madonna, Joy E. Duer, Brock J. McKinney, Enakshi D. Sunassee, Brian T. Crouch, Olga Ilkayeva, Matthew D. Hirschey, James V. Alvarez, Nirmala Ramanujam
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00481-3