The neoepitope landscape of breast cancer: implications for immunotherapy

The neoepitope landscape of breast cancer: implications for immunotherapy

Abstract Background Cancer immunotherapy with immune checkpoint blockade (CKB) is now standard of care for multiple cancers. The clinical response to CKB is associated with T cell immunity targeting cancer-induced mutations that generate novel HLA-binding epitopes (neoepitopes). Methods Here, we dev...

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Bibliographic Details
Main Authors: Pooja Narang, Meixuan Chen, Amit A. Sharma, Karen S. Anderson, Melissa A. Wilson
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
Breast cancer
Neoepitope prediction
Mutation burden
Immunotherapy
TNBC
Epitopes
Online Access:http://link.springer.com/article/10.1186/s12885-019-5402-1

Internet

http://link.springer.com/article/10.1186/s12885-019-5402-1

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