Costunolide ameliorates rotenone-induced Parkinson's disease in rat model via activation of SIRT-1/p-AMPK cascade and suppression of IL-6/STAT3 axis

Costunolide ameliorates rotenone-induced Parkinson's disease in rat model via activation of SIRT-1/p-AMPK cascade and suppression of IL-6/STAT3 axis

Costunolide (COST), a sesquiterpene lactone, has demonstrated promising potential in molecular docking studies targeting key proteins associated with Parkinson's disease (PD), particularly AMP-activated protein kinase (AMPK) and sirtuin-1 (SIRT1). Building on these preliminary findings, this st...

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Bibliographic Details
Main Authors: Alaa Sirwi, Nesrine S. El-Sayed, Dina A.I. Albadawi, Abdulrahman E. Koshak, Sabrin R.M. Ibrahim, Gamal A. Mohamed, Hossam M. Abdallah, Mostafa A. Rabie
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Scientific African
Subjects:
Parkinson's disease
Costunolide
Saussurea lappa
SIRT-1
AMPK
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227624004125

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http://www.sciencedirect.com/science/article/pii/S2468227624004125

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