Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

To investigate the role of the vasculature in pancreatic β-cell regeneration, we crossed a zebrafish β-cell ablation model into the avascular npas4l mutant (i.e. cloche). Surprisingly, β-cell regeneration increased markedly in npas4l mutants owing to the ectopic differentiation of β-cells in the mes...

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Bibliographic Details
Main Authors: Ka-Cheuk Liu, Alethia Villasenor, Maria Bertuzzi, Nicole Schmitner, Niki Radros, Linn Rautio, Kenny Mattonet, Ryota L Matsuoka, Sven Reischauer, Didier YR Stainier, Olov Andersson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
differentiation
beta-cell regeneration
ectopic beta-cells
cellular origin
Online Access:https://elifesciences.org/articles/65758

Internet

https://elifesciences.org/articles/65758

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