Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer’s disease in adult Alzheimer’s model AppNL-G-F mice

Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer’s disease in adult Alzheimer’s model AppNL-G-F mice

IntroductionAlzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (Aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. Many cohort studies indicate that toot...

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Bibliographic Details
Main Authors: Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C. Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kubo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
tooth loss
amyloid-β
phosphorylated tau
microglia
astrocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1361847/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1361847/full

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