Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis

Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis

Abstract Background Accumulating evidence implicates that gut fungi are associated with the pathogenesis of colorectal cancer (CRC). Our previous study has revealed that Candida tropicalis (C. tropicalis) promotes colorectal tumorigenesis by enhancing immunosuppressive function of myeloid-derived su...

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Bibliographic Details
Main Authors: Zhiyong Zhang, Yaojun Zheng, Ying Chen, Yuxin Yin, Yuxi Chen, Qianyu Chen, Yayi Hou, Sunan Shen, Mingming Lv, Tingting Wang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Experimental Hematology & Oncology
Subjects:
Candida tropicalis
Colorectal cancer
Myeloid-derived suppressor cells
Syk
PKM2
Aerobic glycolysis
Online Access:https://doi.org/10.1186/s40164-022-00334-6

Internet

https://doi.org/10.1186/s40164-022-00334-6

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