The SZT2 Interactome Unravels New Functions of the KICSTOR Complex

The SZT2 Interactome Unravels New Functions of the KICSTOR Complex

Seizure threshold 2 (SZT2) is a component of the KICSTOR complex which, under catabolic conditions, functions as a negative regulator in the amino acid-sensing branch of mTORC1. Mutations in this gene cause a severe neurodevelopmental and epileptic encephalopathy whose main symptoms include epilepsy...

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Bibliographic Details
Main Authors: Cecilia Cattelani, Dominik Lesiak, Gudrun Liebscher, Isabel I. Singer, Taras Stasyk, Moritz H. Wallnöfer, Alexander M. Heberle, Corrado Corti, Michael W. Hess, Kristian Pfaller, Marcel Kwiatkowski, Peter P. Pramstaller, Andrew A. Hicks, Kathrin Thedieck, Thomas Müller, Lukas A. Huber, Mariana Eca Guimaraes de Araujo
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
KICSTOR
mTORC1
SZT2
epilepsy
neurogenesis
autophagy
Online Access:https://www.mdpi.com/2073-4409/10/10/2711

Internet

https://www.mdpi.com/2073-4409/10/10/2711

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