Prolactin-Induced Adaptation in Glucose Homeostasis in Mouse Pregnancy Is Mediated by the Pancreas and Not in the Forebrain

Prolactin-Induced Adaptation in Glucose Homeostasis in Mouse Pregnancy Is Mediated by the Pancreas and Not in the Forebrain

Adaptive changes in glucose homeostasis during pregnancy require proliferation of insulin-secreting beta-cells in the pancreas, together with increased sensitivity for glucose-stimulated insulin secretion. Increased concentrations of maternal prolactin/placental lactogen contribute to these changes,...

Full description

Bibliographic Details
Main Authors: Zin Khant Aung, Ilona C. Kokay, David R. Grattan, Sharon R. Ladyman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Endocrinology
Subjects:
prolactin
pregnancy
beta-cell
hypothalamus
prolactin receptor
gestation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.765976/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.765976/full

Similar Items