Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancerResearch in context

Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancerResearch in context

Summary: Background: Tertiary Lymphoid Structures (TLS) correlate with positive outcomes in patients with NSCLC and the efficacy of immune checkpoint blockade (ICB) in cancer. The actin regulatory protein hMENA undergoes tissue-specific splicing, producing the epithelial hMENA11a linked to favorabl...

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Bibliographic Details
Main Authors: Francesca Di Modugno, Anna Di Carlo, Sheila Spada, Belinda Palermo, Lorenzo D'Ambrosio, Daniel D'Andrea, Gaia Morello, Beatrice Belmonte, Isabella Sperduti, Vittoria Balzano, Enzo Gallo, Roberta Melchionna, Mariangela Panetta, Giulia Campo, Francesca De Nicola, Frauke Goeman, Barbara Antoniani, Silvia Carpano, Gianmaria Frigè, Sarah Warren, Filippo Gallina, Diether Lambrechts, Jieyi Xiong, Benjamin G. Vincent, Nathan Wheeler, Dante S. Bortone, Federico Cappuzzo, Francesco Facciolo, Claudio Tripodo, Paolo Visca, Paola Nisticò
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:EBioMedicine
Subjects:
Tumor microenvironment
Tertiary lymphoid structures
Cancer-associated fibroblasts
Immune checkpoint blockade
Resistance to immunotherapy
Epithelial mesenchymal transition
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424000380

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http://www.sciencedirect.com/science/article/pii/S2352396424000380

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