GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

Claspin is essential for activating the DNA damage checkpoint effector kinase Chk1, a target in oncotherapy. Claspin functions are tightly correlated to Claspin protein stability, regulated by ubiquitin-dependent proteasomal degradation. Here we identify Glycogen Synthase Kinase 3-β (GSK3-&...

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Bibliographic Details
Main Authors: Elisa Cabrera, Prahlad Raninga, Kum Kum Khanna, Raimundo Freire
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
Claspin
GSK3-β
DNA damage response
triple negative breast cancer
cancer treatment
Online Access:https://www.mdpi.com/2072-6694/11/8/1073

Internet

https://www.mdpi.com/2072-6694/11/8/1073

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