Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route

Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route

Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations. Therefore, an evaluation of this neurotoxicity from a behavioral perspective is important to reveal sym...

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Bibliographic Details
Main Authors: Chunyan Jia, Su Su Lei Mon, Ying Yang, Maho Katsuyama, Kie Yoshida-Tanaka, Tetsuya Nagata, Kotaro Yoshioka, Takanori Yokota
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
antisense oligonucleotide
intracerebroventricular injection
acute neurotoxicity
central nervous system disease
calcium homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122003316

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http://www.sciencedirect.com/science/article/pii/S2162253122003316

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