Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma. However, little is known about the sphingolipids regulated by nSMase2 and their roles in live...

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Bibliographic Details
Main Authors: Liansheng Zhong, Ji Na Kong, Michael B. Dinkins, Silvia Leanhart, Zhihui Zhu, Stefka D. Spassieva, Haiyan Qin, Hsuan-Pei Lin, Ahmed Elsherbini, Rebecca Wang, Xue Jiang, Mariana Nikolova-Karakashian, Guanghu Wang, Erhard Bieberich
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Lipid Research
Subjects:
sphingolipids
lipid
ceramide
lipidomics
sphingomyelin phosphodiesterase 3
cancer stem-like cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331151

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http://www.sciencedirect.com/science/article/pii/S0022227520331151

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