Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors
A novel series of tri-aryl imidazole derivatives <b>5a</b>–<b>n</b> carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA <b>IX</b> and <b>XII</b> activity. Six compounds were found to be potent and selective...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/16/4718 |