Extracellular histones aggravate autoimmune arthritis by lytic cell death

Extracellular histones aggravate autoimmune arthritis by lytic cell death

Although recent studies have demonstrated a proinflammatory effect of extracellular histones in sepsis via endothelial cytotoxicity, little is known about their contribution to autoimmune arthritis. Therefore, we investigated the role of extracellular histones in autoimmune arthritis and their cytot...

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Bibliographic Details
Main Authors: Jaeyong Jung, Lucy Eunju Lee, Hanna Kim, Ji Eun Kim, Sung Hoon Jang, Jong Seong Roh, Beomgu Lee, William H. Robinson, Dong Hyun Sohn, Jae-Chul Pyun, Jason Jungsik Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
histone
cytotoxicity
DAMP
chemokine
synoviocyte
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.961197/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.961197/full

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