Rufomycin Exhibits Dual Effects Against Mycobacterium abscessus Infection by Inducing Host Defense and Antimicrobial Activities

Rufomycin Exhibits Dual Effects Against Mycobacterium abscessus Infection by Inducing Host Defense and Antimicrobial Activities

Nontuberculous mycobacterial pulmonary infection is often aggravated due to antibiotic resistance issues. There is a need for development of new drugs inducing both host immune responses and antimicrobial activities. This study shows that the rufomycins 4/5/6/7 (Rufomycin 4–7), which targets ClpC1 a...

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Bibliographic Details
Main Authors: Cho Rong Park, Seungwha Paik, Young Jae Kim, Jin Kyung Kim, Sang Min Jeon, Sang-Hee Lee, Jake Whang, Jinhua Cheng, Joo-Won Suh, Jin Cao, Gauri Shetye, Shao-Nong Chen, James McAlpine, Guido F. Pauli, Scott Franzblau, Sanghyun Cho, Eun-Kyeong Jo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium abscessus
rufomycin
inflammation
host immune defense
antimicrobial activity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.695024/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.695024/full

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