Cell Membrane Adaptations Mediate β-Lactam-Induced Resensitization of Daptomycin-Resistant (DAP-R) <i>Staphylococcus aureus</i> In Vitro

Cell Membrane Adaptations Mediate β-Lactam-Induced Resensitization of Daptomycin-Resistant (DAP-R) <i>Staphylococcus aureus</i> In Vitro

The reversal of daptomycin resistance in MRSA to a daptomycin-susceptible phenotype following prolonged passage in selected β-lactams occurs coincident with the accumulation of multiple point mutations in the <i>mprF</i> gene. MprF regulates surface charge by modulating the content and t...

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Bibliographic Details
Main Authors: Nagendra N. Mishra, Arnold S. Bayer, Sarah L. Baines, Ashleigh S. Hayes, Benjamin P. Howden, Christian K. Lapitan, Cassandra Lew, Warren E. Rose
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Microorganisms
Subjects:
CM lipids
daptomycin resistance
resensitization
MRSA
Online Access:https://www.mdpi.com/2076-2607/9/5/1028

Internet

https://www.mdpi.com/2076-2607/9/5/1028

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