SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization

SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization

BackgroundNeuroinflammation has been reported as a potential contributing factor to brain diseases, and is characterized by activated microglia with release of multiple inflammatory mediators. 2,3,5,6-Tetramethylpyrazine (TMP) is an active alkaloid in Ligusticum chuanxiong Hort. and has various biol...

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Bibliographic Details
Main Authors: Yu Chen, Fu Peng, Chao Yang, Huan Hou, Ziwei Xing, Junren Chen, Li Liu, Cheng Peng, Dan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
2
3
5
6-tetramethylpyrazine
neuroinflammation
microglia polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206513/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206513/full

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