Expanding DdCBE-mediated targeting scope to aC motif preference in rat

Expanding DdCBE-mediated targeting scope to aC motif preference in rat

An animal model harboring pathogenic mitochondrial DNA (mtDNA) mutations is important to understand the biological links between mtDNA variation and mitochondrial diseases. DdCBE, a DddA-derived cytosine base editor, has been utilized in zebrafish, mice, and rats for tC sequence-context targeting an...

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Bibliographic Details
Main Authors: Xiaolong Qi, Lei Tan, Xu Zhang, Jiachuan Jin, Weining Kong, Wei Chen, Jianying Wang, Wei Dong, Lijuan Gao, Lijun Luo, Dan Lu, Jianan Gong, Feifei Guan, Wenjie Shu, Xingxu Huang, Lianfeng Zhang, Shengqi Wang, Bin Shen, Yuanwu Ma
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA editing
mitochondrial DNA editing
DdCBE
aC motif
mitochondrial disease model
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000483

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http://www.sciencedirect.com/science/article/pii/S2162253123000483

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