Cannabidiol effectively prevents oxidative stress and stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) in an animal model of global hypoxia

Cannabidiol effectively prevents oxidative stress and stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) in an animal model of global hypoxia

Abstract Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis sativa. It has therapeutic effects in different paradigms of brain injury, acting as a neuroprotectant. As oxidative stress is a primary risk factor for brain damage after neonatal hypoxia, we tested the effec...

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Bibliographic Details
Main Authors: Hanna Kletkiewicz, Michał S. Wojciechowski, Justyna Rogalska
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Subjects:
Perinatal hypoxia
Cannabidiol
Oxidative stress
Lipid peroxidation
Antioxidants
Hypoxia-inducible factor-1 alpha
Online Access:https://doi.org/10.1038/s41598-024-66599-5

Internet

https://doi.org/10.1038/s41598-024-66599-5

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