Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

Abstract GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and hi...

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Bibliographic Details
Main Authors: Lien Wang, Grace Lee, Amy Shih, Chester Kuei, Diane Nepomuceno, Michelle Wennerholm, Frances Fan, Jiejun Wu, Pascal Bonaventure, Timothy W. Lovenberg, Changlu Liu
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Pharmacology Research & Perspectives
Subjects:
calcium mobilization assay
gain of function
GPR139
homology model
random mutagenesis
reduction of function
Online Access:https://doi.org/10.1002/prp2.466

Internet

https://doi.org/10.1002/prp2.466

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