Ropivacaine inhibits wound healing by suppressing the proliferation and migration of keratinocytes via the PI3K/AKT/mTOR Pathway

Ropivacaine inhibits wound healing by suppressing the proliferation and migration of keratinocytes via the PI3K/AKT/mTOR Pathway

Abstract Background After surgery, millions of people suffer from delayed healing or wound dehiscence with subsequent severe complications, even death. Previous studies have reported that ropivacaine exhibits anti-proliferative and anti-migratory activities on numerous cells. Whether ropivacaine is...

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Bibliographic Details
Main Authors: Xiaoyang Wu, Quanyu Sun, Simeng He, Ya Wu, Shihan Du, Lirong Gong, Jianbo Yu, Haifeng Guo
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Anesthesiology
Subjects:
Ropivacaine
Wound healing
PI3K
AKT
mTOR Pathway
Online Access:https://doi.org/10.1186/s12871-022-01646-0

Internet

https://doi.org/10.1186/s12871-022-01646-0

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