Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms

Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms

Tau is a microtubule-associated protein known to bind and promote assembly of microtubules in neurons under physiological conditions. However, under pathological conditions, aggregation of hyperphosphorylated tau causes neuronal toxicity, neurodegeneration, and resulting tauopathies like Alzheimer’s...

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Bibliographic Details
Main Authors: Kaylin Hwang, Rahil N. Vaknalli, Kwaku Addo-Osafo, Mariane Vicente, Keith Vossel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
tau
epilepsy
mTOR
hyperexcitability
hyperphosphorylation of tau
cognitive decline
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.903973/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.903973/full

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