Expression of Immunoglobulin Receptors with Distinctive Features Indicating Antigen Selection by Marginal Zone B Cells from Human Spleen

Expression of Immunoglobulin Receptors with Distinctive Features Indicating Antigen Selection by Marginal Zone B Cells from Human Spleen

Abstract Marginal zone (MZ) B cells, identified as surface (s)IgMhighsIgDlowCD23low/−CD21+CD38− B cells, were purified from human spleens, and the features of their V(D)J gene rearrangements were investigated and compared with those of germinal center (GC), follicular mantle (FM) and switched memory...

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Bibliographic Details
Main Authors: Monica Colombo, Giovanna Cutrona, Daniele Reverberi, Silvia Bruno, Fabio Ghiotto, Claudya Tenca, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Jenny Ceccarelli, Sandra Salvi, Simona Boccardo, Maria Grazia Calevo, Amleto De Santanna, Mauro Truini, Franco Fais, Manlio Ferrarini
Format: Article
Language:English
Published: BMC 2013-07-01
Series:Molecular Medicine
Subjects:
Antigen Selection
Intraclonal Diversification
Recurrent Sequence
Activation-induced Cytidine Deaminase (AID)
Follicular Mantle (FM)
Online Access:https://doi.org/10.2119/molmed.2013.00069

Internet

https://doi.org/10.2119/molmed.2013.00069

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