Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration

Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. The complement system has been identified as one of the main AMD disease pathways. We performed a comprehensive expression analysis of 32 complement proteins in plasma samples of 255 AMD pa...

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Bibliographic Details
Main Authors: I. Erkin Acar, Esther Willems, Eveline Kersten, Jenneke Keizer-Garritsen, Else Kragt, Bjorn Bakker, Tessel E. Galesloot, Carel B. Hoyng, Sascha Fauser, Alain J. van Gool, Yara T. E. Lechanteur, Elod Koertvely, Everson Nogoceke, Jolein Gloerich, Marien I. de Jonge, Laura Lorés-Motta, Anneke I. den Hollander
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Journal of Personalized Medicine
Subjects:
age-related macular degeneration
AMD
complement system
semi-quantitative multiplex profilin
mass spectrometry
C4
Online Access:https://www.mdpi.com/2075-4426/11/12/1256

Internet

https://www.mdpi.com/2075-4426/11/12/1256

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