Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron-specific activators p35/p39 and plays important roles in neuronal development, synaptic plasticity, and cognitive behavior. However, the proteolytic cleavage of p35 to p25 leads to prolonged and aberrant Cd...

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Bibliographic Details
Main Authors: YaLi Wang, JianHua Zhao, Fang-Li Guo, XiaHuan Gao, Xine Xie, ShouQing Liu, Xin Yang, XinFeng Yang, LuYi Zhang, YuXiao Ye, LiBing Fan, JianGang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
AD
Cdk5
p35
p25
metformin
synapse
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00170/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00170/full

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