Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron-specific activators p35/p39 and plays important roles in neuronal development, synaptic plasticity, and cognitive behavior. However, the proteolytic cleavage of p35 to p25 leads to prolonged and aberrant Cd...

Full description

Bibliographic Details
Main Authors: YaLi Wang, JianHua Zhao, Fang-Li Guo, XiaHuan Gao, Xine Xie, ShouQing Liu, Xin Yang, XinFeng Yang, LuYi Zhang, YuXiao Ye, LiBing Fan, JianGang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
AD
Cdk5
p35
p25
metformin
synapse
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00170/full

Similar Items

Similar Items