The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator

The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator

Abstract Background In the vascular compartment, the serine protease tissue-type plasminogen activator (tPA) promotes fibrinolysis, justifying its clinical use against vasculo-occlusive diseases. Accumulating evidence shows that circulating tPA (endogenous or exogenous) also controls brain physiopat...

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Bibliographic Details
Main Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lazarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien, Carine Ali
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Fluids and Barriers of the CNS
Subjects:
Tissue-type plasminogen activator
Choroid plexus
Epithelium
Low density lipoprotein receptor-related protein
Barrier
Transport
Online Access:https://doi.org/10.1186/s12987-022-00378-0

Internet

https://doi.org/10.1186/s12987-022-00378-0

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