Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2

Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2

Severe Acute respiratory syndrome coronavirus (SARS-CoV-1) attaches to the host cell surface to initiate the interaction between the receptor-binding domain (RBD) of its spike glycoprotein (S) and the human Angiotensin-converting enzyme (hACE2) receptor. SARS-CoV-1 mutates frequently because of its...

Full description

Bibliographic Details
Main Authors: Adebiyi Sobitan, Vidhyanand Mahase, Raina Rhoades, Dejaun Williams, Dongxiao Liu, Yixin Xie, Lin Li, Qiyi Tang, Shaolei Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
computational saturation mutagenesis
spike missense mutations
SARS-CoV-1
SARS-CoV-2
protein stability
binding affinity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.784303/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.784303/full

Similar Items