Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium

Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium

Abstract Background Histone modifications play a critical role in chromatin remodelling and regulate gene expression in health and disease. Histone methyltransferases EZH1, EZH2, and demethylases UTX, JMJD3, and UTY catalyse trimethylation of lysine 27 on histone H3 (H3K27me3). This study was design...

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Bibliographic Details
Main Authors: Julia Sánchez-Ceinos, Shafaat Hussain, Abdul Waheed Khan, Liang Zhang, Wael Almahmeed, John Pernow, Francesco Cosentino
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cardiovascular Diabetology
Subjects:
Diabetes
Epigenetics
Endothelial cells
Oxidative stress
Inflammation
Chromatin-modifying drugs
Online Access:https://doi.org/10.1186/s12933-024-02196-0

Internet

https://doi.org/10.1186/s12933-024-02196-0

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