Identification of a common polymorphism in COQ8B acting as a modifier of thoracic aortic aneurysm severity

Identification of a common polymorphism in COQ8B acting as a modifier of thoracic aortic aneurysm severity

Summary: Thoracic aortic aneurysm (TAA) predisposes to sudden, life-threatening aortic dissection. The factors that regulate interindividual variability in TAA severity are not well understood. Identifying a molecular basis for this variability has the potential to improve clinical risk stratificati...

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Bibliographic Details
Main Authors: Benjamin J. Landis, Dongbing Lai, Dong-Chuan Guo, Joel S. Corvera, Muhammad T. Idrees, Henry W. Stadler, Christian Cuevas, Gavin U. Needler, Courtney E. Vujakovich, Dianna M. Milewicz, Robert B. Hinton, Stephanie M. Ware
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:HGG Advances
Subjects:
thoracic aortic aneurysm
aortic dissection
Marfan syndrome
bicuspid aortic valve
genetic modifier
coenzyme Q
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247721000385

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http://www.sciencedirect.com/science/article/pii/S2666247721000385

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