T-Cell Immunodeficiencies With Congenital Alterations of Thymic Development: Genes Implicated and Differential Immunological and Clinical Features

T-Cell Immunodeficiencies With Congenital Alterations of Thymic Development: Genes Implicated and Differential Immunological and Clinical Features

Combined Immunodeficiencies (CID) are rare congenital disorders characterized by defective T-cell development that may be associated with B- and NK-cell deficiency. They are usually due to alterations in genes expressed in hematopoietic precursors but in few cases, they are caused by impaired thymic...

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Bibliographic Details
Main Authors: Giuliana Giardino, Carla Borzacchiello, Martina De Luca, Roberta Romano, Rosaria Prencipe, Emilia Cirillo, Claudio Pignata
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
Thymus
FOXN1 gene
PAX1 gene
Pax 1/9
CHARGE
CHD7 gene
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01837/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01837/full

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