Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report
Granulocyte colony-stimulating factor (G-CSF)-producing urothelial carcinomas (UCs) are rare and have a poor prognosis. According to the literature, treatment for G-CSF-producing UCs is very difficult. We experienced 2 cases of UC presenting with leukocytosis. In these cases, serum G-CSF levels were...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-04-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/472250 |
| _version_ | 1828279344766648320 |
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| author | Kento Morozumi Shunichi Namiki Takashi Kudo Masataka Aizawa Naomasa Ioritani |
| author_facet | Kento Morozumi Shunichi Namiki Takashi Kudo Masataka Aizawa Naomasa Ioritani |
| author_sort | Kento Morozumi |
| collection | DOAJ |
| description | Granulocyte colony-stimulating factor (G-CSF)-producing urothelial carcinomas (UCs) are rare and have a poor prognosis. According to the literature, treatment for G-CSF-producing UCs is very difficult. We experienced 2 cases of UC presenting with leukocytosis. In these cases, serum G-CSF levels were higher than the reference value with leukocytosis at diagnosis, and the resected specimens were positive for anti-G-CSF immunostaining. One case had a good prognosis and the other case died after 9 months from diagnosis. A change in serum G-CSF levels was reportedly an effective tumor marker in several reports. In the present cases, evaluation of serum G-CSF levels was found to be more sensitive than computerized tomography. The treatment and outcomes of UC-producing G-CSFs and the efficacy of serum G-CSF as a tumor marker are discussed based on our cases and a review of the literature. |
| first_indexed | 2024-04-13T07:42:24Z |
| format | Article |
| id | doaj.art-6008c746b79a4696a40baadf36e47b89 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T07:42:24Z |
| publishDate | 2017-04-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-6008c746b79a4696a40baadf36e47b892022-12-22T02:55:51ZengKarger PublishersCase Reports in Oncology1662-65752017-04-0110137738210.1159/000472250472250Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case ReportKento MorozumiShunichi NamikiTakashi KudoMasataka AizawaNaomasa IoritaniGranulocyte colony-stimulating factor (G-CSF)-producing urothelial carcinomas (UCs) are rare and have a poor prognosis. According to the literature, treatment for G-CSF-producing UCs is very difficult. We experienced 2 cases of UC presenting with leukocytosis. In these cases, serum G-CSF levels were higher than the reference value with leukocytosis at diagnosis, and the resected specimens were positive for anti-G-CSF immunostaining. One case had a good prognosis and the other case died after 9 months from diagnosis. A change in serum G-CSF levels was reportedly an effective tumor marker in several reports. In the present cases, evaluation of serum G-CSF levels was found to be more sensitive than computerized tomography. The treatment and outcomes of UC-producing G-CSFs and the efficacy of serum G-CSF as a tumor marker are discussed based on our cases and a review of the literature.http://www.karger.com/Article/FullText/472250Granulocyte colony-stimulating factorImage evaluationTumor markerTherapyUrothelial carcinoma |
| spellingShingle | Kento Morozumi Shunichi Namiki Takashi Kudo Masataka Aizawa Naomasa Ioritani Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report Case Reports in Oncology Granulocyte colony-stimulating factor Image evaluation Tumor marker Therapy Urothelial carcinoma |
| title | Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report |
| title_full | Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report |
| title_fullStr | Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report |
| title_full_unstemmed | Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report |
| title_short | Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report |
| title_sort | serum g csf may be a more valuable biomarker than image evaluation in g csf producing urothelial carcinoma a case report |
| topic | Granulocyte colony-stimulating factor Image evaluation Tumor marker Therapy Urothelial carcinoma |
| url | http://www.karger.com/Article/FullText/472250 |
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