Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Abstract DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ). The balance of these pathways is dependent on the local chromatin context, but the underlying mechanisms are poorly understood. By combining...

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Bibliographic Details
Main Authors: Xabier Vergara, Anna G. Manjón, Marcel de Haas, Ben Morris, Ruben Schep, Christ Leemans, Anoek Friskes, Roderick L. Beijersbergen, Mathijs A. Sanders, René H. Medema, Bas van Steensel
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-49232-x

Internet

https://doi.org/10.1038/s41467-024-49232-x

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