The Influence of Mitochondrial-DNA-Driven Inflammation Pathways on Macrophage Polarization: A New Perspective for Targeted Immunometabolic Therapy in Cerebral Ischemia-Reperfusion Injury

The Influence of Mitochondrial-DNA-Driven Inflammation Pathways on Macrophage Polarization: A New Perspective for Targeted Immunometabolic Therapy in Cerebral Ischemia-Reperfusion Injury

Cerebral ischemia-reperfusion injury is related to inflammation driven by free mitochondrial DNA. At the same time, the pro-inflammatory activation of macrophages, that is, polarization in the M1 direction, aggravates the cycle of inflammatory damage. They promote each other and eventually transform...

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Bibliographic Details
Main Authors: Sihang Yu, Jiaying Fu, Jian Wang, Yuanxin Zhao, Buhan Liu, Jiahang Wei, Xiaoyu Yan, Jing Su
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
cerebral ischemia-reperfusion
mtDNA
inflammation
macrophages
immune metabolism
STING
Online Access:https://www.mdpi.com/1422-0067/23/1/135

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https://www.mdpi.com/1422-0067/23/1/135

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