Golgi fucosyltransferase 1 reveals its important role in α-1,4-fucose modification of N-glycan in CRISPR/Cas9 diatom Phaeodactylum tricornutum

Golgi fucosyltransferase 1 reveals its important role in α-1,4-fucose modification of N-glycan in CRISPR/Cas9 diatom Phaeodactylum tricornutum

Abstract Phaeodactylum tricornutum (Pt) is a critical microbial cell factory to produce a wide spectrum of marketable products including recombinant biopharmaceutical N-glycoproteins. N-glycosylation modification of proteins is important for their activity, stability, and half-life, especially some...

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Bibliographic Details
Main Authors: Xihui Xie, Jianchao Yang, Hong Du, Jichen Chen, Edmond Sanganyado, Yangmin Gong, Hua Du, Weizhou Chen, Zhengyi Liu, Xiaojuan Liu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Microbial Cell Factories
Subjects:
Phaeodactylum tricornutum
Glycoprotein
Fucosyltransferase
N-glycan
Microbial cell factory
Online Access:https://doi.org/10.1186/s12934-022-02000-2

Internet

https://doi.org/10.1186/s12934-022-02000-2

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