Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88

Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88

Porphyromonas gingivalis is a gram-negative anaerobic periodontal pathogen that persists in dysbiotic mixed-species biofilms alongside a dense inflammatory infiltrate of neutrophils and other leukocytes in the subgingival areas of the periodontium. Toll-like receptor 2 (TLR2) mediates the inflammato...

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Bibliographic Details
Main Authors: Hasnaa Makkawi, Shifra Hoch, Elia Burns, Kavita Hosur, George Hajishengallis, Carsten J. Kirschning, Gabriel Nussbaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
P. gingivalis
immune evasion
TLR2 signaling
MyD88
PI3 kinase
neutrophils
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00359/full

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http://journal.frontiersin.org/article/10.3389/fcimb.2017.00359/full

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