Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

Abstract Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the accumulation of CpG>TpG transition...

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Bibliographic Details
Main Authors: Thomas Chabot, Fariba Nemati, Aurélie Herbette, Alexandre Demeyer, Stéphane Dayot, Olivier Ganier, Samar Alsafadi, Sophie Gardrat, Pascale Mariani, Marie Luporsi, Maxime Corbé, Vincent Servois, Nathalie Cassoux, Didier Decaudin, Sergio Roman Roman, Elaine Del Nery, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00326-z

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https://doi.org/10.1038/s41698-022-00326-z

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