Computational biotechnology guides elucidation of the biosynthesis of the plant anticancer drug camptothecin

Computational biotechnology guides elucidation of the biosynthesis of the plant anticancer drug camptothecin

Camptothecin is a clinically important monoterpene indole alkaloid (MIAs) used for treating various cancers. Currently, the production of this biopharmaceutical hinges on its extraction from camptothecin-producing plants, leading to high market prices and supply bottlenecks. While synthetic biology...

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Bibliographic Details
Main Authors: Emily Amor Stander, Thomas Dugé de Bernonville, Nicolas Papon, Vincent Courdavault
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Medicinal plants
Next-generation sequencing
Genome mining
Pharmaceuticals
Biosynthetic pathway
Synthetic biology
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702100266X

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http://www.sciencedirect.com/science/article/pii/S200103702100266X

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