STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
Fifty patients with chronic autoimmune urticaria (CAU) and forty-eight patients with chronic idiopathic urticaria (CIU) have been examined. Blood serum contents of IL-4, IL-10 and IL-17A, spontaneous and induced cytokine production in blood cells, as well as polymorphism of IL-4 (C-589T), IL-10 (G-1...
| Główni autorzy: | , , |
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| Format: | Artykuł |
| Język: | Russian |
| Wydane: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2015-04-01
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| Seria: | Медицинская иммунология |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.mimmun.ru/mimmun/article/view/835 |
| Streszczenie: | Fifty patients with chronic autoimmune urticaria (CAU) and forty-eight patients with chronic idiopathic urticaria (CIU) have been examined. Blood serum contents of IL-4, IL-10 and IL-17A, spontaneous and induced cytokine production in blood cells, as well as polymorphism of IL-4 (C-589T), IL-10 (G-1082A), IL-17A (G-197A) cytokine genes has been studied. No differences have been detected when studying IL-4 levels, depending on genetic variants of IL-4 gene in patients with CAU and CIU. Increased IL-10 amounts in patients with CIU still did not show any correlations with IL-10 genotype (G-1082A). Increased IL-17A levels in patients with CAU were associated with homozygous genotype of AA in comparison to control group, and with heterozygous GA genotype, in comparison to CIU group. The revealed differences of cytokines` genes polymorphism in CAU and CIU provide a molecular-genetic evidence for different clinical forms of chronic urticaria. |
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| ISSN: | 1563-0625 2313-741X |