Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc–ODC1 nexus

Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc–ODC1 nexus

Abstract Background Hypoxia contributes to cancer progression through various molecular mechanisms and hepatocellular carcinoma (HCC) is one of the most hypoxic malignancies. Hypoxia-inducible gene domain protein-1a (HIGD1A) is typically induced via epigenetic regulation and promotes tumor cell surv...

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Bibliographic Details
Main Authors: Haixing Zhang, Xiaoran Li, Ziying Liu, Zimo Lin, Kuiyuan Huang, Yiran Wang, Yu Chen, Leyi Liao, Leyuan Wu, Zhanglian Xie, Jinlin Hou, Xiaoyong Zhang, Hongyan Liu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cancer & Metabolism
Subjects:
Hepatocellular carcinoma (HCC)
Hypoxia-induced gene domain protein-1a (HIGD1A)
c-Myc
Ornithine decarboxylase 1 (ODC1)
Polyamine metabolism
Online Access:https://doi.org/10.1186/s40170-024-00334-6

Internet

https://doi.org/10.1186/s40170-024-00334-6

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