Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression

Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression

Abstract Background Ovarian cancer is the most common malignant tumor of the female reproductive tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However, the mechanism underlying epithelial ovarian cancer (EOC) chemoresistance is not completely uncovered. The phosphat...

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Bibliographic Details
Main Authors: Junli Deng, Xupeng Bai, Xiaojie Feng, Jie Ni, Julia Beretov, Peter Graham, Yong Li
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Ovarian cancer
Chemoresistance
EMT
CSC
PI3K/Akt/mTOR signaling
Online Access:http://link.springer.com/article/10.1186/s12885-019-5824-9

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http://link.springer.com/article/10.1186/s12885-019-5824-9

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