Immunohistochemical assessment and clinical, histopathologic, and molecular correlates of membranous somatostatin type-2A receptor expression in high-risk pediatric central nervous system tumors

Immunohistochemical assessment and clinical, histopathologic, and molecular correlates of membranous somatostatin type-2A receptor expression in high-risk pediatric central nervous system tumors

Introduction177Lu-DOTATATE, a radionuclide therapy that binds somatostatin type-2A receptors (SST2A), has demonstrated efficacy in neuroendocrine tumors and evidence of central nervous system (CNS) penetration, supporting potential expansion within pediatric neuro-oncology. Understanding the prevale...

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Bibliographic Details
Main Authors: Margot A. Lazow, Christine Fuller, Andrew T. Trout, Joseph R. Stanek, Jaime Reuss, Brian K. Turpin, Sara Szabo, Ralph Salloum
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
somatostatin receptor
SST2A
immunohistochemistry
pediatric CNS tumors
embryonal tumors
medulloblastoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.996489/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.996489/full

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